ALPHABETICAL LISTINGS OF QUINOLONE DRUGS
This is not a complete List of Quinolones and Fluoroquinolones that have been in existence. There are thousands of quinolones and related drugs, often with different generic names for the same drug, so be aware of the drugs that you are taking and look them up yourself if you have experienced toxicity from these drugs. If you are not familiar with these drugs, please see our Introduction to Fluoroquinolones. The following is a list of the various chemical names. This list is evolving all of the time as new drugs are being developed.
The different classes denote different chemical substitutions at different points in the chemical structure for various therapeutic reasons. See DrugBank.ca or see the History of the Fluoroquinolones from structure to activity to toxicity powerpoint for more specific information on the chemical makeup of each of these various drugs, if you are interested in that type of in-depth information. These different chemical substitutions also cause unique problems in the human body, from a higher risk of collagen disruptions such as Tendon Rupture and Aortic Aneurysm, to DNA Damage, and much much more..
Be aware that, “The distinction between a quinolone drug and a fluoroquinolone drug is the addition of the fluorine atom to the pharmcore, resulting in a fluorinated drug. The terms fluoroquinolone and quinolone are often used interchangeably, without regard to this distinction” From Fluoroquinolone Toxicity. Even more importantly, it’s vital to understand that Half of All Antibiotic Use is Unnecessary, so be aware and read the rest of this site to understand the dangers involved when you take these drugs, and what you can do to avoid being prescribed these drugs unnecessarily.
Fluoroquinolone with an N-1 Substitution
Ciprofloxacin- One of the most prescribed fluoroquinolones
Gemifloxacin- Associated with toxic necrolytic skin reactions
Grepafloxacin- withdrawn from use in 1999 (1)
Norfloxacin- use indicated only for urinary tract infections (1)
Fluoroquinolones with a C-5 Substitution
Grepafloxacin- Continued cardiac issues caused it to be removed from use
Sparfloxacin- Known to cause a muscle wasting problem called rhabdomyolysis
Fluoroquinolones with a C-7 Substitition
Fleroxacin- High rates of phototoxicity, which Increases Skin Cancer Risk
Levofloxacin – Also called Levaquin. One of the top 3 most prescribed Fluoroquinolones
Lomefloxacin- High rates of phototoxicity, leading to an Increased Skin Cancer Risk
Sparfloxacin- High rates of phototoxicity, or damage to user from sunlight exposure
Fluoroquinolones with a Position C-8 Substitution
Lomefloxacin- The halide at C-8 linked to toxicity when exposed to sunlight (1)
Sparfloxacin- The halide at C-8 linked to toxicity when user exposed to sunlight (1)
Temafloxacin- Linked to hemolytic anemia, kidney and liver damage, and blood sugar impairment (1)
Tosufloxacin- Linked to toxic reactions when user exposed to sunlight (1)
Marbofloxacin (Also called Zeniquin and is one of the Fluoroquinolones Used for Dogs and Cats)
Mefloquine – An Antimalarial drug that can lead to serious mental illness and 5 times the risk of suicide
The Non-Fluorinated Quinolones
QUINOLONES That Have Been Removed From Use
- Clinafloxacin- The halide at C-8 linked to toxicity when exposed to sunlight (1) and severe blood sugar issues
- Enrofloxacin (Also called Baytril and used in veterinary medicine)
- Grepafloxacin- Withdrawn from use in 1999 due to deadly heart rhythm known as a Prolonged QT Interval (1)
- Nalidixic acid
- Temafloxacin (Omniflox) – Recalled 6 months after FDA approval due to Deadly Blood Coagulation Problems as well as kidney and liver failure(1). See the FDA Press Release on the Recall of Omniflox.
- Trovafloxacin- Not removed, but restricted to use only in hospitals since 1999. Severe liver damage (1) (3)
- Sparfloxacin- Withdrawn in most countries due to toxicity upon user sunlight exposure and DNA Damage (2)
QUINOLONES Used in Veterinary Medicine
Aurizon (marbofloxacin in a topical cream)
These drugs also need to be used cautiously in pets. Please see our page on Levaquin for Dogs, as they can lead to serious problems in dogs, cats, and even rabbits.
(1) Safety of Fluoroquinolones- an Update
(2) Fluoride Alert Network- Phototoxic Fluoroquinolones
(3) Fluoroquinolones, from structure to activity to toxicity (powerpoint in pdf form)